KMID : 0988920180160010075
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Intestinal Research 2018 Volume.16 No. 1 p.75 ~ p.82
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Efficacy of restarting anti-tumor necrosis factor ¥á agents after surgery in patients with Crohn's disease
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Hiraoka Sakiko
Takashima Shiho Kondo Yoshitaka Inokuchi Toshihiro Sugihara Yuusaku Takahara Masahiro Kawano Seiji Harada Keita Kato Jun Okada Hiroyuki
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Abstract
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Background/Aims: The efficacy of anti-tumor necrosis factor ¥á (anti-TNF¥á) antibodies for postoperative Crohn's disease (CD) in patients who were treated with these agents prior to surgery is largely unknown.
Methods: CD patients who underwent intestinal resection and received anti-TNF¥á agents after surgery were divided into 2 groups according to the presence or absence of preoperative anti-TNF¥á treatment: anti-TNF¥á restart group or anti-TNF¥á naive group. Endoscopic recurrence after surgery was examined according to the preoperative conditions, including administration of anti-TNF¥á agents before surgery.
Results: Thirty-six patients received anti-TNF¥á antibody after surgery: 22 in the anti-TNF¥á restart group and 14 in the anti-TNF¥á naive group. Endoscopic recurrence after surgery was more frequently observed in the anti-TNF¥á restart group than in the anti-TNF¥á naive group (68% vs. 14%, P<0.001). Multivariate analysis revealed the following significant risk factors of endoscopic recurrence after surgery: anti-TNF restart group (odds ratio [OR], 28.10; 95% CI, 3.08?722.00), age at diagnosis <23 years (OR, 24.30; 95% CI, 1.67?1,312.00), serum albumin concentration at surgery <3.3 g/dL (OR, 34.10; 95% CI, 1.72?2,804.00), and presence of inflammation outside of the surgical site (OR, 21.40; 95% CI, 1.02?2,150.00). Treatment intensification for patients with endoscopic recurrence in the anti-TNF¥á restart group showed limited responses, with only 1 of 12 patients achieving endoscopic remission.
Conclusions: The efficacy of restarting anti-TNF¥á antibody treatment after surgery was limited, and treatment intensification or a change to different classes of biologics should be considered for those patients.
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KEYWORD
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Crohn disease, Anti-tumor necrosis factor ¥á, Surgery
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